Research Paper Volume 12, Issue 23 pp 23778—23794
Colon cancer combined with obesity indicates improved survival- research on relevant mechanism
Figure 5. Obesity was associated with repression of immune checkpoints. (A) The expression of various immune checkpoints in obesity and normal groups. (B) The expression of LAG3 and PD-1 in healthy bowel tissues, colon cancer derived from normal (non-obesity) patients and obesity patients was confirmed by immunohistochemistry. (C) The association of drug sensitiveness and gene expression (LAG3 and PD-1) analyzed by Genomics of Drug Sensitivity in Cancer (GDSC) database. (D) The correlation matrix of each immune checkpoint in obesity and normal group. (*p<0.05, **p<0.01).