Functional enrichment analysis for the significant DEGs and identification of hub genes. (A, C) The top ten enriched biological processes of the significantly upregulated DEGs and downregulated DEGs, respectively. (B, D) The top ten enriched KEGG pathways of the significantly upregulated DEGs and downregulated DEGs, respectively. (E, F) The top 20 hub genes of the significantly upregulated DEGs and downregulated DEGs separately.