Research Paper Volume 12, Issue 19 pp 19233—19253

CDR1as knockdown inhibits the growth of HB cells in vivo. (A) Image of BALB/c nude mice that were subcutaneously injected with HepG2 cells (2 × 10⁶ cells per mouse; n = 3 per group); (B) The tumor volume of mice was measured weekly; (C) Image of subcutaneous xenograft tumors; (D) Tumor weights were significantly decreased in sh-CDR1as-treated mice; (E) Immunohistochemistry (IHC) of Ki-67 and KLF4 in the subcutaneous tumors; (F) Schematic illustration showing the relationship demonstrated in our study. Scale bar, 200 μm. Data are presented as the mean ± SEM of three experiments, *P < 0.05, **P < 0.01 (Student’s t-test).