Research Paper Volume 12, Issue 14 pp 13958—13978
Decreased autophagy and fuel switching occur in a senescent hepatic cell model system
Figure 6. RT-qPCR analysis of SASP-related proinflammatory genes in senescent AML12 cells and liver tissues from young and old mice. RT-qPCR analysis of SASP-related proinflammatory genes in senescent AML12 cells (A) and liver tissues from young and old mice (B). (C) RT-qPCR analysis of inflammatory interleukins, chemokine CCL2 and fibrotic IL11 genes in control AML12 cells treated with conditional media from senescent AML12 cells (24 h) along with or without saturated fatty acids palmitate (0.5 mM for 24 h). Statistical differences were calculated significant as *p<0.05, **p<0.01, and ****p<0.0001.