Research Paper Volume 12, Issue 20 pp 20163—20183
Down-regulated ciRS-7/up-regulated miR-7 axis aggravated cartilage degradation and autophagy defection by PI3K/AKT/mTOR activation mediated by IL-17A in osteoarthritis
Effects of the PI3K/Akt/mTOR pathway on the expression of cartilage degradation-related proteins and autophagy-related proteins in IL-1β-induced chondrocytes. Representative Western blot analysis and band intensity analysis showing protein levels of MMP3, MMP13, ADAMTS5, Beclin1, and LC3 in chondrocytes that received different treatments. Data represent the mean ± SD (n = 3), * p < 0.05, ** p < 0.01 and *** p < 0.001 vs. the IL-1β group.