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Research Paper Volume 12, Issue 20 pp 20152—20162

Polymerase I and transcript release factor transgenic mice show impaired function of hematopoietic stem cells

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PTRF impaired HSCs function partly through Cav-1. (A) Number of colonies generated by LT-HSCs from PTRF+Cav-1-/- and WT mice (n=3). (B) The percentage of donor-derived cells in the PB of PTRF+Cav-1-/- and WT mice at 4, 8, and 12 weeks post-transplantation. (C, D) The percentage of donor-derived B (C) and M cells (D) from PTRF+Cav-1-/- and WT mice in the PB at 4, 8, and 12 weeks post-transplantation. n=9 mice per group. Data represent the mean ± SD.