Research Paper Volume 12, Issue 18 pp 18396—18414
Elevated serum IL-21 levels are associated with stable immune status in kidney transplant recipients and a mouse model of kidney transplantation
Figure 6. Exogenous IL-21 promotes active kidney rejection in mice. (A and B) Expression of C4d in the allograft (scale bar: 250μm). Histopathology scores of glomerulities, tubulitis, I, PTC, and V (C–G) of the kidney allografts from Control, KT, and IL-21+KT recipients. Values represent mean (±SEM). *P < 0.05, **P < 0.01, and ***P < 0.001. PTC, peritubular capillaritis; I, interstitial inflammation; V, intimal arteritis; IL, interleukin; KT, kidney transplant; SEM, standard error of the mean.