Modeling mtDNA hypermethylation vicious circle mediating Aβ-induced endothelial damage memory in HCMEC/D3 cell

HaoChen Liu; Hong Zhang; Yixuan Zhang; Sheng Xu; Huimin Zhao; Hua He; XiaoQuan Liu

doi:doi:10.18632/aging.103699

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Research Paper Volume 12, Issue 18 pp 18343—18362

Modeling mtDNA hypermethylation vicious circle mediating Aβ-induced endothelial damage memory in HCMEC/D3 cell

Figure 3. (A) The change of AKG, MMP, and cell vitality in decitabine treated hCMEC/D3 cell. The control group data is normalized to 100%. (B) The change of mtDNA methylation, MMP, and cell vitality in AKG treated hCMEC/D3 cell. The control group data is normalized to 100%. ** p<0.01 * p<0.05.