Research Paper Volume 12, Issue 19 pp 19022—19044
Target RNA modification for epigenetic drug repositioning in neuroblastoma: computational omics proximity between repurposing drug and disease
GO, KEGG pathway enrichment analysis and the gene set enrichment analysis (GSEA) of differentially expressed genes (DEGs) in two groups. (A) Biological process of GO analysis; (B) Cellular component of GO analysis; (C) Molecular function of GO analysis; (D) KEGG pathways analysis. Y-axis: name of enrichment item; X-axis: gene count in each item (positive value for cluster1 and negative for cluster2); gradient color of the bar chart: -Log2_Pvalue (values >0 for -Log2_Pvalue in Cluster1, and values <0 for -(-Log2_Pvalue) in Cluster2). (E) GSEA enrichment plots in HALLMARK datasets from left to right: MYC targets, E2F targets, unfolded protein response, and MTORC1 signaling. In each plot, top panels: enrichment score (ES) for each gene; bottom panels: the ranking metrics of each gene; Y-axis: ranking metric values; X-axis: ranks for all genes. NES: normalized ES. Norm P (nominal p value): the statistical significance of the observed ES for this plot. FDR q value: a significantly enriched enrichment plot if q< 0.25.