NLRP3 activation in endothelia promotes development of diabetes-associated atherosclerosis

Dong Huang; Wei Gao; Xin Zhong; Junbo Ge

doi:doi:10.18632/aging.103666

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Research Paper Volume 12, Issue 18 pp 18181—18191

NLRP3 activation in endothelia promotes development of diabetes-associated atherosclerosis

Figure 6. NLRP3/ caspase-1/IL-1β are depleted in endothelial cells in APOEKO/Tie2p-Cre/NLRP3^MKO mice. The knockdown of NLRP3/ caspase-1/IL-1β cascades in APOEKO/Tie2p-Cre/NLRP3^MKO mice was confirmed on CD31+ endothelial cells isolated from mouse aortic arch. (A, B) NLRP3 levels by RT-qPCR (A) and by ELISA (B). (C, D) IL-1β (C) and caspase 1 (D) levels by ELISA. *p<0.05. NS: non-significant. N=5.