Figure 2.Inhibition of LncRNA XIST restrains tumor formation ability, cell proliferation and migration and enhances apoptosis in gastric cancer. The SGC7901 cells were transfected with siRNAs targeting XIST, namely, si-XIST-1 and si-XIST-2. (A) The expression of lncRNA XIST determined by RT-qPCR; (B) Cell proliferation ability assessed by EdU assay (× 400); (C) Cell migration ability evaluated by scratch test (× 40); (D) Cell apoptosis ability evaluated by flow cytometry; (E) The effect of lncRNA XIST on tumor formation in nude mice injected with the stably transfected SGC7901 cells. All measurement data and statistical results were expressed as mean ± standard deviation; *, p < 0.05 compared with cells transfected with si-NC or the mice injected with si-NC-transfected cells; comparisons were conducted using one-way ANOVA. The experiment was repeated 3 times.
