Figure 3 — Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome

Research Paper|Volume 12, Issue 15|pp. 15414–15435

Depletion of exosomal circLDLR in follicle fluid derepresses miR-1294 function and inhibits estradiol production via CYP19A1 in polycystic ovary syndrome

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Figure 3.KEGG pathway analysis of the parental genes of differentially expressed circRNA candidates. (A) The most significantly enriched pathways: ovarian steroidogenesis, aldosterone synthesis and secretion, thyroid hormone signaling pathway, ubiquitin mediated proteolysis, Jak-STAT signaling pathway, and endocytosis. (B) The diagrammatic sketch of ovarian steroidogenesis pathway in which circLDLR (hsa_circ_0006877) is involved.