Research Paper Volume 12, Issue 14 pp 15021—15036
NVD-BM-mediated genetic biosensor triggers accumulation of 7-dehydrocholesterol and inhibits melanoma via Akt1/NF-ĸB signaling
Figure 1. Heterogeneous cholesterol 7-desaturases inhibits melanoma cell growth. (A, B) Quantification of GAPDH, NVD-BM, DAF-36, NVD-DR, MGC154819 and TTHERM_00310640 gene expression using RT-qPCR in A375 and A2058 cells. (C, D) A375 and A2058 cell proliferation transfected with genes expressing different cholesterol 7-desaturases at 24 h. (***p < 0.001)