Figure 1. Genetic alterations and PPI network of 36 FRGs in the TCGA pan-cancer datasets. (A) Diagrammatic representation shows intracellular localization of ferroptosis-related proteins in different signaling pathways. (B) The protein-protein interaction network analysis results of 36 ferroptosis-related genes (FRGs) are shown. (C) The copy number variation (CNV) frequency of the 36 FRGs is shown for the 32 cancer types. The color code bar on the right refers to differential gain or loss of copy numbers. (D) The single nucleotide variation (SNV) frequency of the 36 FRGs is shown for the 32 cancer types. The color code bar on the right refers to differential SNV frequencies.