Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT
Figure 3.DCTPP1 and QPRT promoted the invasion and growth of BC cells. MCF-7 and T47D cells were transfected with shRNA-DCTPP1, shRNA-QPRT, and DCTPP1 and QPRT expression vectors. The migration (A) and invasion (B) of BC cells were inhibited after DCTPP1 and QPRT knockdown, but enhanced after DCTPP1 and QPRT overexpression. The bar in the pictures (B) indicates a length of 5 μm. (C) As indicated by the tumour xenograft assay, silencing DCTPP1 or QPRT inhibited the growth of MCF-7 and T47D cells in nude mice. MCF-7 and T47D cells overexpressing DCTPP1 or QPRT showed notably faster growth than that by MCF-7 and T47D control cells. *P<0.05 and **P<0.01 vs. control group.