Figure 5.Relationships between neoantigen burden and patient response undergo immunotherapy treatment. For van Allen cohort, the somatic neoantigen burden was significant associated with patient response to immunotherapy treatment (Wilcoxon test, P=0.031, A), while AS neoantigen burden was not associated with response (Wilcoxon test, P=0.93, C). For Hugo cohort, the somatic neoantigen burden was not associated with response (Wilcoxon test, P=0.37, B), while AS neoantigen burden was significant associated with response (Wilcox test, P=0.029, D). Overall neoantigen burden showed no association with response neither in van Allen cohort (Wilcox test, P=0.24, E) nor in Hugo cohort (Wilcox test, P=0.2, F). CB: Clinical Benefit, NCB: No Clinical Benefit.
