Research Paper Volume 12, Issue 14 pp 14434—14451
Characterization of aberrant pathways activation and immune microenviroment of BK virus associated nephropathy
Figure 1. BKVN was associated with increased levels of activated memory CD4 T cells and their cell markers. (A) The proportions of activated memory CD4 T cells in the PB (STA and BKV), TKB1 (STA and BKVN) and TKB2 (STA and BKVN) datasets. (B) Comparison of the expression of cell markers of activated memory CD4 T cells between TKB1 (STA and BKVN) and TKB2 (STA and BKVN). The thick line represents the median value. The bottom and top of the boxes indicate the 25th and 75th percentiles (interquartile range). The whiskers encompass 1.5 times the interquartile range. *, P< 0.05; **, P< 0.01; ***, P< 0.001; and ****, P<0.0001; Mann-Whitney U test.