Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy <i>via</i> the SIRT1-FOXO1 signaling pathway

Zhi-Gang Mei; Ya-Guang Huang; Zhi-Tao Feng; Ya-Nan Luo; Song-Bai Yang; Li-Peng Du; Kang Jiang; Xiao-Lu Liu; Xian-Yun Fu; Yi-Hui Deng; Hua-Jun Zhou

doi:doi:10.18632/aging.103420

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Research Paper Volume 12, Issue 13 pp 13187—13205

Electroacupuncture ameliorates cerebral ischemia/reperfusion injury by suppressing autophagy via the SIRT1-FOXO1 signaling pathway

Figure 3. EA pretreatment inhibited the formation of autophagosomes and autophagolysosomes (yellow arrow) in cortical neurons of rats with CIR injury. (A) Autophagosomes and autophagolysosomes in neurons of the peri-ischemic cortex in the sham group (a and b) and the I/R group (c and d). (B) Autophagosomes and autophagolysosomes in neurons of the peri-ischemic cortex in the I/R + EA group (e and f) and the I/R + EA + EX527 group (g and h). The images of b, d, f, and h indicated the enlarged area of the squares in a, c, e, and g, respectively. Scale bar: a, c, e, g, 5 μm; b, d, f, h, 2 μm.