Research Paper Volume 12, Issue 18 pp 17902—17920

Figure 8. The effect of SBF2-AS1 on tumor growth in vivo. (A) Representative pictures of tumor xenograft. (B–C) Quantitative analysis of xenografted tumor volume and weight. (D) The level of SBF2-AS1 in sh-SBF2-AS1 group and sh-Con group was detected by qRT-PCR assay. (E) Representative IHC staining images and relative expression levels of ADAM17 positive staining in tumor sections from sh-SBF2-AS1 group and sh-Con group. (F) The levels of ADAM17, MMP-2 and MMP-9 in sh-SBF2-AS1 group and sh-Con group were detected by wester blotting assay. (G) The level of miR-338-3p in sh-SBF2-AS1 group and sh-Con group was detected by qRT-PCR assay. ^**P<0.01 compared with sh-Con group. (H) Representative macroscopic pictures of mice lung, twelve weeks after inoculation (right panel). Representative photographs of H&E stained spontaneous lung metastases (left panel). (I) Graph displaying the total number of tumor nodules per lung in sh-Con and sh-SBF2-AS1 group. (J) Schematic model of SBF2-AS1-mediated the growth, migration and invasion in NSCLC cell. ^**P<0.01 compared with sh-Con group.