Figure 9.Schematic mechanism underlying CUEDC1-suppressed NSCLC progression. CUEDC1 interacts and upregulates Smurf2 expression; then, Smurf2 inactivates the TβRI/Smad signaling pathway, thereby reversing EMT and reducing the ability for tumor metastasis, inhibiting cell cycle progression, and promoting cell apoptosis to suppress tumor growth.
