Research Paper Volume 12, Issue 10 pp 9515—9533
Clioquinol improves motor and non-motor deficits in MPTP-induced monkey model of Parkinson’s disease through AKT/mTOR pathway
Figure 6. CQ play neuroprotective effect by improving AKT/mTOR survival pathway and blocking p53 medicated cell death. (A–D) Western bolts and quantification showed decreased expression of phosphor-AKT (S473 and T308), phosphor-mTOR (S2448) and Bcl-2, as well as increased p-p53 and Bax in the SN of monkeys, and which were reversed by both LD and CQ treatment. (E–H) Western bolts and quantification showed decreased expression of phosphor-AKT (S473 and T308), phosphor-mTOR (S2448) and Bcl-2, as well as increased p-p53 and Bax in SK-N-SH cells, and which were reversed by CQ treatment. Data expressed as the mean ± SD. *P<0.05, **P<0.01, indicate significant difference.