Figure 2 — Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway

Research Paper|Volume 12, Issue 7|pp. 6058–6066

Aspirin alleviates hepatic fibrosis by suppressing hepatic stellate cells activation via the TLR4/NF-κB pathway

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Figure 2.Aspirin reduces expression of profibrogenic associated mediators and TLR4. (A–C) mRNA expression of early markers of fibrogenesis including α-SMA, collagen-a1 and TGF-β1 was detected by real-time PCR. (D) Western blot was employed to detect the expression ofα-SMA, collagen-a1 and TGF-β1 in liver tissues. (E, F) TLR4 expression was tested by real-time PCR and immunochemistry analysis. (×200; scale bar: 100μm) ^*P<0.05, ^**P<0.01.