Figure 4. The effect of uric acid on extending life span depends on its regulation of the IIS signaling pathway. Survival analysis of (A) daf-16 (mu86), (B) daf-2 (e1370), (C) hsf-1 (sy441) mutant worms treated with 2 mM uric acid and of the untreated control (P value by log-rank test). The life span values of the repeat experiments are summarized in