HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the <i>Axin1</i>-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

Guangping Zhang; Luzhu Chen; Jing Liu; Yan Jin; Zaihong Lin; Shu Du; Zenghui Fu; Tuantuan Chen; Yinghui Qin; Fenghu Sui; Yan Jiang

doi:doi:10.18632/aging.102636

← Back

Research Paper Volume 12, Issue 5 pp 4067—4081

HIF-1α/microRNA-128-3p axis protects hippocampal neurons from apoptosis via the Axin1-mediated Wnt/β-catenin signaling pathway in Parkinson’s disease models

Figure 5. The pathological changes of hippocampal neurons in the MPTP-lesioned mouse model of PD. (A) The ultrastructure of hippocampal neurons treated with si-Hif1a or oe-Hif1a to electron microscopy. (B) The pathological changes of hippocampal neurons treated with si-Hif1a or oe-Hif1a revealed by HE staining (scale bar = 50 μm). (C) The apoptosis of hippocampal neurons treated with si-Hif1a or oe-Hif1a detected by TUNEL staining (scale bar = 50 μm). * p < 0.05 vs. the NC group (MPTP-lesioned mice treated with NC plasmids). N = 10.