Downregulation of ABI2 expression by EBV-miR-BART13-3p induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells through upregulation of c-JUN/SLUG signaling

Jing Huang; You Qin; Chensu Yang; Chao Wan; Xiaomeng Dai; Yajie Sun; Jingshu Meng; Yanwei Lu; Yan Li; Zhanjie Zhang; Bian Wu; Shuangbing Xu; Honglin Jin; Kunyu Yang

doi:doi:10.18632/aging.102618

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Research Paper Volume 12, Issue 1 pp 340—358

Downregulation of ABI2 expression by EBV-miR-BART13-3p induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells through upregulation of c-JUN/SLUG signaling

Figure 4. The effect of down-regulated ABI2 on NPC cells is similar to that of overexpressed EBV-miRNA-BART13-3p. (A) Western blot showed that knockdown of ABI2 by siRNA was effective. Downregulation of ABI2 caused decreased expression of E-cadherin and increased expression of Vimentin. (B, C) Transwell assay showed that siABI2 enhances migration and invasion of CNE1 and S26 cells. Right panel: quantification. Scale bar, 100μm. Error bars represent SEM. (*P<0.05; **P<0.01; ***P<0.001).