Downregulation of ABI2 expression by EBV-miR-BART13-3p induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells through upregulation of c-JUN/SLUG signaling

Jing Huang; You Qin; Chensu Yang; Chao Wan; Xiaomeng Dai; Yajie Sun; Jingshu Meng; Yanwei Lu; Yan Li; Zhanjie Zhang; Bian Wu; Shuangbing Xu; Honglin Jin; Kunyu Yang

doi:doi:10.18632/aging.102618

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Research Paper Volume 12, Issue 1 pp 340—358

Downregulation of ABI2 expression by EBV-miR-BART13-3p induces epithelial-mesenchymal transition of nasopharyngeal carcinoma cells through upregulation of c-JUN/SLUG signaling

Figure 2. EBV-miR-BART13-3p induces EMT of NPC cells. (A) Cell morphological changes after transient transfection of BART13-3p in CNE1 and S26 cells. Scale bar, 100μm. Western blot (B), immunofluorescence (C) and immunohistochemistry (D) all showed that BART13-3p overexpression contributes to decrease of E-cadherin and increase of Vimentin in NPC cells or in NPC tumor specimens. Scale bar, 20μm (C) and 100μm (D). (*P<0.05; **P<0.01; ***P<0.001).