Research Paper Volume 11, Issue 24 pp 12685—12707

Combination of lymphocyte number and function in evaluating host immunity

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Figure 5. The number and function of lymphocytes in different disease models. (A) Scatter plots showing the number and function of CD4+, CD8+ T cells, and NK cells in patients with hypoproteinemia (n=58), diabetes (n=40), lung cancer (n=37), post-chemotherapy (n=32), uremia (n=33), kidney transplantation (n=61), hepatic failure (n=49), liver transplantation (n=33), and matched healthy controls. (B) Scatter plots showing the number and function of CD4+, CD8+ T cells, and NK cells in patients with SLE (n=33), RA (n=30), MCTD (n=31), UC (n=31), SS (n=30), AIH (n=30), and matched healthy controls. (C) Scatter plots showing the number and function of CD4+, CD8+ T cells, and NK cells in patients with aspergillus infection (n=22), HPV infection (n=38), TP infection (n=34), HIV infection (n=19), PC infection (n=31), CN infection (n=11), and matched healthy controls. Horizontal lines indicate the median. *P < 0.05, **P < 0.01, ***P < 0.001 (Mann–Whitney U-test). SLE, systemic lupus erythematosus; RA, rheumatoid arthritis; MCTD, mixed connective tissue diseases; UC, ulcerative colitis; SS, Sjögren syndrome; AIH, autoimmune hepatitis; HPV, human papillomavirus; TP, Treponema pallidum; HIV, human immunodeficiency virus; PC, Pneumocystis carinii; CN, Cryptococcus neoformans.