Figure 2 — FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells

Research Paper|Volume 11, Issue 24|pp. 12581–12599

FOXP3 pathogenic variants cause male infertility through affecting the proliferation and apoptosis of human spermatogonial stem cells

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Figure 2.Morphology and phenotype of FOXP3-mut NOA patients and OA controls. (A) H&E staining revealed that seminiferous tubule diameter was reduced and spermatogenesis was arrested in FOXP3-mut NOA patients. Scale bars = 40 μm and 20 μm, respectively. (B-C) Immunohistochemical staining demonstrated the expression of FOXP3 protein (B) and UCHL1 protein (C) in FOXP3-mut NOA patients (low panels) and OA controls (upper panels). Experiments were repeated for at least three times. Scale bars = 20 μm.