Figure 2. TMT-based proteomic analysis of expression of identified proteins in LI72h, MI72h and HI72h HepG2 cells. (A) Identification of clustered protein expression profiles by STEM. Model profiles (black) and the matched experimental protein expression profiles (red) are shown. Each box shows a profile identification number (upper left) and an unadjusted p value (lower left). Colored boxes represent model profiles assigned more proteins than expected by chance. (B) GO analysis of cellular components (red), biological process (green) and molecular function (blue) for 520 regulated proteins. 102 proteins involved in the term ‘mitochondrion’ were further analyzed by BiNGO plugin in Cytoscape. The node size corresponds to the number of proteins assigned to an individual term; p-value < 0.05 was defined as significant (yellow) and a darker color represents a lower p-value. See also