Figure 8. SEC14L2 is a potential HCC suppressor. (A) Calculation of dES and survival responses for SEC14L2 in the HCC6 cohort. (B) GO terms enrichment analysis of SEC14L2 regulon. (C) KEGG pathway enrichment analysis of SEC14L2 regulon. (D) Representative target genes of SEC14L2 regulon were significantly up-regulated after SEC14L2 overexpression. (E) SEC14L2 overexpression significantly inhibited cell proliferation (CCK-8 assay) and colony formation in HCC cell lines. Upper and lower panels show corresponding results in MHCC97-H cells. These assays were repeated in Huh7 cells (