A phenolic amide (LyA) isolated from the fruits of <i>Lycium barbarum</i> protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway

Kai Gao; Meiyou Liu; Yi Ding; Minna Yao; Yanrong Zhu; Jinyi Zhao; Lianghua Cheng; Juan Bai; Fan Wang; Jinyi Cao; Jiankang Li; Haifeng Tang; Yanyan Jia; Aidong Wen

doi:doi:10.18632/aging.102578

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Research Paper Volume 11, Issue 24 pp 12361—12374

A phenolic amide (LyA) isolated from the fruits of Lycium barbarum protects against cerebral ischemia–reperfusion injury via PKCε/Nrf2/HO-1 pathway

Figure 4. Effects of LyA and OGD on cell viability. (A) Cells were incubated in different concentrations of LyA alone. (B) MTT assay was employed to investigate the protective effect of LyA against OGD-induced cytotoxicity. (C) Cell death was further confirmed by measuring LDH leakage. Data were represented as means ± SD (n=6). ^* p < 0.05 compared with control group; ^# p < 0.05 compared with OGD group.