Research Paper Volume 12, Issue 1 pp 53—69
FHL3 promotes pancreatic cancer invasion and metastasis through preventing the ubiquitination degradation of EMT associated transcription factors
Figure 6. FHL3 knockdown inhibited pancreatic tumor growth and metastasis in vivo. (A) experiments process in vivo. (B) tumor volume of PANC1_KD1 and PANC1_NC, 4 weeks after orthotopic transplantation; and the tumor volume of PANC1_KD1 group was about 1/3 of PANC1_NC group, p<0.01. (C) FHL3 knockdown made the weaker Ki67 staining in tumor sections of PANC1_KD1 group. (D) H&E staining of tumor section. (E) IHC staining of FHL3 of tumor section. (F1a, F1b) lung metastasis from circular pancreatic tumor cells, and FHL3 knockdown made the lower occurrent rate of lung metastasis in PANC1_KD1 and BXPC3_KD1 groups, p<0.05. (F2a, F2b) hepatic metastasis from orthotopic transplantation tumor, and FHL3 knockdown made the lower occurrent rate of hepatic metastasis in PANC1_KD1 and BXPC3_KD1 groups, p<0.05.