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Research Paper Volume 11, Issue 23 pp 11520—11540

Bone morphogenetic protein 4 (BMP4) alleviates hepatic steatosis by increasing hepatic lipid turnover and inhibiting the mTORC1 signaling axis in hepatocytes

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Figure 5. BMP4 down-regulates the mTORC1 signaling pathway in mouse liver. The liver samples prepared in Figure 3 were used for the following assays. (A) Total cell lysate was prepared from the retrieved liver samples and subjected to Western blotting analysis of the expression of the members of mTORC1 signaling pathway. (B) The retrieved liver samples were paraffin-embedded, sectioned and subjected to IHC staining to detect the expression of the members of mTORC1 signaling pathway and lipid metabolism. Each assay condition was done in triplicate, and representative images are shown.