Research Paper Volume 11, Issue 23 pp 11416—11439

Figure 5. Identification of upstream potential miRNAs of GJB2, S100A2 and SPOCK2 by combination of miRNA prediction, survival analysis and correlation analysis. (A) The miRNA-GJB2 network established by Cytoscape. (B) The miRNA-S100A2 network established by Cytoscape. (C) The miRNA-SPOCK2 network established by Cytoscape. (D) Prognostic values (overall survival, OS) of potential upstream miRNAs of GJB2 in TCGA ovarian cancer cohort. (E) Prognostic values (overall survival, OS) of potential upstream miRNAs of S100A2 in TCGA ovarian cancer cohort. (F) Prognostic values (overall survival, OS) of potential upstream miRNAs of SPOCK2 in TCGA ovarian cancer cohort. Green bars indicate a favorable prognosis; red bars indicate an unfavorable prognosis; black bars represent no statistical significance. (G) The expression correlation of hsa-miR-105-5p and GJB2 in ovarian cancer. (H) The expression correlation of hsa-miR-522-3p and GJB2 in ovarian cancer. (I) The expression correlation of hsa-miR-421 and S100A2 in ovarian cancer. (J) The expression correlation of hsa-miR-363-3p and SPOCK2 in ovarian cancer. (K) The expression correlation of hsa-miR-362-3p and SPOCK2 in ovarian cancer. (L) The expression correlation of hsa-miR-942-5p and SPOCK2 in ovarian cancer.