Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

Chen Diling; Guo Yinrui; Qi Longkai; Tang Xiaocui; Liu Yadi; Yang Xin; Hu Guoyan; Shuai Ou; Yong Tianqiao; Wang Dongdong; Xie Yizhen; Burton B. Yang; Wu Qingping

doi:doi:10.18632/aging.102529

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Research Paper Volume 11, Issue 24 pp 12002—12031

Circular RNA NF1-419 enhances autophagy to ameliorate senile dementia by binding Dynamin-1 and Adaptor protein 2 B1 in AD-like mice

Figure 2. CircRNAs expression in D-galactose-induced deficits astrocyte. (A) 7376 astroglia circRNAs were identified and their types were showed; (B) Different expression of circRNAs in D-galactose induced aging astrocyte; (C) Time series analysis of circRNAs positively correlated to the degree of aging; Different expression of circRNAs in D2 (D); Aging regulates circRNAs as circ_NF1-419 (circ_000978), circ_002671, circ_003172, circ_CTGF-212, circ_SIRT1-395, circ_002276, circ_SIRT1-623, circ_001215, circ_001216 and circ_000987 were validated by reverse transcription polymerase chain reaction in cultured astrocyte (E, F). D0 (culture without 20 g/L D-galactose), D1 (culture in 20 g/L D-galactose for one generations) and D2 (culture in 20 g/L D-galactose for two generations) (Figure 2C, 2D), D3 (culture in 20 g/L D-galactose for three generations). Data are presented as the means ± SD of 3 independent experiments. **p <0.01 vs. the control group (D0) by one-way ANOVA, followed by the Holm-Sidak test.