Figure 9.Schematic model of apoptotic melanocyte death mediated by FADS1 downregulation. Downregulation of FADS1 increases reactive oxygen species (ROS) generation, which led to inhibition of the p38/ERK MAPK signaling pathway. Furthermore, Downregulation of FADS1 induces apoptosis and cell cycle arrest in PIG1 cells via inhibition of the p38/ERK MAPK signaling pathway.
