Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo

Luyan Tang; Jian Li; Wenwen Fu; Wenyu Wu; Jinhua Xu

doi:doi:10.18632/aging.102452

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Research Paper Volume 11, Issue 24 pp 11829—11843

Suppression of FADS1 induces ROS generation, cell cycle arrest, and apoptosis in melanocytes: implications for vitiligo

Figure 9. Schematic model of apoptotic melanocyte death mediated by FADS1 downregulation. Downregulation of FADS1 increases reactive oxygen species (ROS) generation, which led to inhibition of the p38/ERK MAPK signaling pathway. Furthermore, Downregulation of FADS1 induces apoptosis and cell cycle arrest in PIG1 cells via inhibition of the p38/ERK MAPK signaling pathway.