Research Paper Volume 11, Issue 19 pp 8329—8346

Figure 3. SA-T cells accumulate in lacrimal glands of aged mice, particularly in female mice. (A and B) Naïve (CD44^loCD62L^hi) and effector memory (CD44^hiCD62L^lo) expression in CD4⁺ T cells (A), or PD-1⁺CD153⁺ expression in effector memory CD4⁺ T cells (B) in the lacrimal glands of young and aged mice. Results are representative of those from each group of mice. (C and D) Proportions (N=5) (C) and numbers adjusted by the lacrimal gland (LG) weight (N=4) (D) of PD-1⁺CD153⁺ cells gated on effector memory CD4⁺ T cells in the LG of young and aged mice. (E) CD153 mRNA expression levels in the LG of young and aged female mice, and of female mice fed a normal diet (ND) or high-fat diet (HFD) for 8 weeks (N=4-5). Values are presented as means ± SEM. *p<0.05 and **p<0.01 (an unpaired Student’s t-test).