Research Paper Volume 11, Issue 15 pp 5351—5367
Long intergenic non-protein coding RNA 511 promotes the progression of osteosarcoma cells through sponging microRNA 618 to upregulate the expression of maelstrom
Figure 8. MiR-618 promotes the tumor activity of OS cells in vitro. (A) Specific siRNA inhibited the expression of MAEL mRNA in HOS cells. (B) MAEL protein expression was dramatically lower in the si-MEAL group than in the NC group. (C–E) CCK-8, colony formation and transwell assays of the proliferation, migration and invasion abilities of HOS cells with MAEL silencing. (C) CCK-8 assay for cell viability. (D) Colony formation assay for cell proliferation. (E) Transwell assays for cell migration and invasion. *P<0.05 and **P<0.01 compared to the NC group.