Figure 4 — Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD

Research Paper|Volume 11, Issue 13|pp. 4654–4671

Ambient particulate matter attenuates Sirtuin1 and augments SREBP1-PIR axis to induce human pulmonary fibroblast inflammation: molecular mechanism of microenvironment associated with COPD

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Figure 4.NLRP3 inflammasome was upregulated by PM exposure. (A) mRNA level of NLRP3 after PM in HPF. (B) Western blot analysis of NLRP3 and IL-1β after PM in HPF. (C) mRNA level of NLRP3 in Ex527-PM co-treated HPF models. (D) mRNA levels of NLRP3 in PF429242-PM co-treated HPF models. (E) Western blot analysis of PIR, SREBP1, and NLRP3 in TPh A-PM co-treated HPF models.