Figure 11.Schematic representation of resveratrol induced activation of AMPK/ SIRT1/ PGC1α and inhibition of mTOR, leading to increased mitochondrial quality. Resveratrol treatment enhances AMPK/SIRT1/PGC1α expression and decreases mTOR signaling, which leads to an increase in mtDNA quality and enhanced energy metabolism at least partly through decreased mitochondrial fragmentation and increased autophagy/mitophagy.
