Research Paper Volume 11, Issue 1 pp 240—248

Metformin prolongs lifespan through remodeling the energy distribution strategy in silkworm, Bombyx mori

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Figure 1. Metformin increases the adult and total mean lifespan in the male silkworm. (A) Adult stage (n=27), (B) mean total lifespan (n=30), and (C) maximum lifespan (n=3) of unmated female silkworms administered metformin (Treatment) or deionized water (Control). (D) Adult stage (n=24), (E) mean total lifespan (n=54) and (F) maximum lifespan of unmated male silkworms administered metformin (Treatment) of deionized water (Control). Bars depict the mean + SEM, *P < 0.05, **P < 0.01, ***P < 0.001.