Editorial Volume 10, Issue 11 pp 3065—3066

Figure 1. Light input to the circadian clock is impaired through age induced cellular changes in the circadian clock- impacting entrainment of sleep wake rhythms. Light is decoded by the eye; however little changes are seen in the aged eye with respects to input into the circadian clock. In fact, it is the clock itself that displays a decline in its ability to interpret this information, through alterations in glutamatergic signalling via the NMDA receptor; which ultimately result in global physiological desynchronization leading to implications in health and wellbeing.