Research Paper Volume 10, Issue 11 pp 3229—3248

Figure 1. TG treatment improved Hcy-induced learning and spatial memory impairments. Sixty male SD rats were divided into 5 groups as Control, Homocysteine only (HHcy), Low TG treatment (Low TG), High TG treatment (High TG) and Positive Control (SCR1693) groups. The rats were subjected to 3 trials per day to find the hidden platform in the Morris Water Maze (MWM) and the memory and learning abilities of the animals were tested for 60s on the seventh day. (A) Escape latency to find the hidden platform in MWM for the six training days. (B) First crossing latency and (C) mean number of crossing the position of the hidden platform on the test day. (D) Time spent and (E) distance traveled in the target quadrant on the test day. (F) Average speed during the 60s of the test. HHcy rats showed impaired spatial learning and memory and treatment with either low or high TG rescued these impairments. The data were expressed as mean ± SEM (n = 12). # P < 0.05, ## P < 0.01, ### P < 0.001, #### P < 0.0001 versus control and * P < 0.05, ** P < 0.01, *** P < 0.001, **** P < 0.0001 versus HHcy.