Research Paper Volume 10, Issue 10 pp 2800—2815
Epigenetic ageing is distinct from senescence-mediated ageing and is not prevented by telomerase expression
Figure 1. Effects of hTERT on growth and epigenetic ageing of human primary neonatal fibroblasts. (A) Growth dynamics of primary cells from two different donors (A and B) transduced with either empty vector (control) or hTERT expressing vector (hTERT). The ages of a selection of cell passages of donor A (B) and donor B (C) were imputed by the pan-tissue clock (left panel) or the skin & blood clock (right panel). The ages are plotted against cumulative population doubling (CPD) that corresponded to the passage of cells that were analysed.