Figure 3. Long-term EE initiated at middle age reduces adiposity and improves metabolism. (A) Time line. (B) Body weight (n=10 per group). (C) Absolute (left) and relative (right) food intake 8~10.5 months in EE. (D) Glucose tolerance test at 32-week in EE (n=10 per group). (E) Body and tissue weight at the age of 22 months after 12-month EE (n=8 per group). (F) Serum biomarkers at sacrifice (n=8 per group). * P<0.05, ** P<0.01, *** P<0.001. Values are means ± SEM.