Figure 7. The functions of E2Fs and genes significant associated with E2Fs alterations were predicted by analysis of Gene Ontology (GO) by DAVID (Database for Annotation, Visualization, and Integrated Discovery) tools (https://david.ncifcrf.gov/summary.jsp). GO enrichment analysis predicted the functional roles of target host genes based on three aspects including biological processes (A), cellular components (B), and molecular functions (C).