Figure 13 — Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

Research Paper|Volume 10, Issue 2|pp. 229–240

Exploiting mitochondrial targeting signal(s), TPP and bis-TPP, for eradicating cancer stem cells (CSCs)

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Figure 13.TPP-related compounds provide a novel chemical strategy for targeting “bulk” cancer cells and CSCs, while minimizing off-target side-effects in normal cells. Our results suggest that “malignant” mitochondria are functionally distinct from “normal” mitochondria. See text for further details.