Research Paper Volume 9, Issue 12 pp 2559—2586

Figure 1. mRNAs differentially expressed upon HUVEC exposure to H₂O₂. Gene Ontology enrichment analysis of the transcriptomic changes induced by HUVEC treatment with H₂O₂ as assessed by rRNA-depleted RNA-sequencing. Circles represent specific ontology terms or KEGG pathways that were significantly enriched in the list of differentially expressed genes after 16 hrs (A) or 36 hrs (B) of H₂O₂ treatment (n= 3). Edges represent term connections within the ontology tree and colors highlight terms correlated in meaning. Terms are captioned if they are the most significant of the group or if they show a biological meaning connected to the system under analysis.