Research Paper Volume 9, Issue 11 pp 2436—2452

Figure 2. Functional differentiation profile of CD4⁺ and CD8⁺ T-cells in patients with polypoidal choroidal vasculopathy (PCV), patients with neovascular age-related macular degeneration (nAMD), and healthy controls. Cells were defined as naïve T-cells CD45ra⁺CD45ro^-CCR7⁺, central memory T-cells (CM) CD45ra^-CD45ro⁺CCR7⁺, effector memory T-cells (EM) CD45ra^-CD45ro⁺CCR7^-, and effector memory CD45ra⁺ T-cells (EMRA) CD45ra⁺CD45ro⁺CCR7^-. These subsets were separately identified in CD4⁺ T-cells (A) and CD8⁺ T-cells (B). (C) We found no significant differences between patients with PCV, patients with nAMD, and healthy controls (P > 0.05 for all comparisons using Kruskal-Wallis test). (D) Age-related changes in the ratio of memory to naïve T-cells indicated no age-related change in CD4⁺ T-cells, but a clear age-related increase in CD8⁺ T-cells that appeared stronger in patients with nAMD.