The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in <i>Drosophila melanogaster</i>

Laura C.D. Pomatto; Sarah Wong; Caroline Carney; Brenda Shen; John Tower; Kelvin J. A. Davies

doi:doi:10.18632/aging.101218

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Research Paper Volume 9, Issue 4 pp 1153—1185

The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster

Figure 2. Adaptation to hydrogen peroxide declines with age in females. Progeny of the Actin-GS-255B strain crossed to the w[1118] strain were aged to 3 days and 60 days prior to H₂O₂ pretreatment. Following recovery, flies were fed H₂O₂ challenge dose: 4.4M in 3 day old males and females, 2M in 60 day old females, and 1M in 60 day old males. (A) 3 day old females showed increased survival following pretreatment. (B) 3 day old males showed no change in survival following pretreatment. (C) With age, 60 day old females no longer show increased survival. (D) 60 day old males show no change in adaptation following pretreatment. Statistical difference in survival (p < 0.05) was calculated using the Log-Rank test. Statistical summary is located in Supplementary Table S1.